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IMMUNOADHESINS, CD4
Descriptors Found:
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DeCS
Descriptor
English
:
CD4 Immunoadhesins
Descriptor
Spanish
:
Inmunoadhesinas CD4
Descriptor
Portuguese
:
Imunoadesinas CD4
Synonyms
English
:
CD4 IgG
CD4-IgG
Immunoadhesins, CD4
Tree Number:
D12.644.541.500.697.249
D12.776.124.486.485.538.500.249
D12.776.124.486.485.680.697.249
D12.776.124.790.651.538.500.249
D12.776.124.790.651.680.660.249
D12.776.377.715.548.538.500.249
D12.776.377.715.548.680.660.249
D12.776.395.550.200.230
D12.776.543.550.200.230
D12.776.828.300.200
D23.050.301.350.230
Definition
English
:
Chimeric molecules resulting from the fusion of recombinant soluble CD4 to the Fc portion of
immunoglobulins
. These have potential use in the therapy of AIDS since they possess both the gp120-binding and HIV-blocking properties of rCD4 as well as the long
plasma
half-life
and Fc receptor-binding functions of immunoglobulin.
Pharmacological Action:
Immunologic Factors
History Note
English
:
92; was CD4 IMMUNOADHESIN (NM) 1989-91
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CH
chemistry
CL
classification
CT
contraindications
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
30208
Unique Identifier:
D016860
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS